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氨基酸螯合铁(Amino acid chelated iron)对动物吸收的影响

文章发表时长:2024-11-26 15:45

在动物消化道中微量金属元素离子与氨基酸类物质常常形成1:1(M/M)的螯合物  ,也由于1:1(M/M)的不稳定螯合物(H和强配位体的影响)金属离子可以与其他非氨基酸配合物(如植酸、草酸、磷酸)形成稳定而“无效”的螯合物不容易被动物吸收利用 。不过氨基酸螯合物稳定常数适中  ,有一定抗酸能力  ,克服植酸不利影响  ,有利于消化吸收 。氨基酸螯合铁的稳定常数均界于4-10之间  ,这利于铁的吸收、运输和利用 。植酸与铁结合的稳定常数更高  ,这也是植物性饲料中铁利用率极低的主要原因 。动物对氨基酸螯合铁的分子量要求范围较宽 。动物试验已经证明了甘氨酸铁和蛋氨酸铁的有效性  ,而它们的分子量分别是206 和354 。另外  ,当动物处于特殊生理时期时(如初生时)  ,可以以“胞饮”的方式吸收动物自身合成的大分子物质(如乳铁蛋白  ,分子量达到几万)  ,这为氨基酸螯合铁的实际应用提供了又一理论基础 。

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Effect of amino acid chelated iron on animal absorption

In the digestive tract of animals, trace metal element ions often form 1:1 (M/M) chelates with amino acids, and because of the 1:1 (M/M) unstable chelates (H and strong ligand), metal ions can form stable and "ineffective" chelates with other non-amino acid complexes (such as phytic acid, oxalic acid, phosphoric acid), which are not easy to be absorbed and utilized by animals. However, the amino acid chelate stability constant is moderate, has a certain acid resistance, overcome the adverse effects of phytic acid, is conducive to digestion and absorption. The stability constant of amino acid chelated iron is between 4 and 10, which is conducive to the absorption, transportation and utilization of iron. The stability constant of phytic acid combined with iron is higher, which is also the main reason for the extremely low iron utilization rate in plant feed. The range of molecular weight required by animals for amino acid chelated iron is wide. Animal studies have demonstrated the effectiveness of iron glycine and iron methionine, and their molecular weights are 206 and 354, respectively. In addition, when the animal is in a special physiological period (such as at the beginning of life), it can absorb the macromolecular substances synthesized by the animal itself (such as lactoferrin, with a molecular weight of tens of thousands) in a "pinocytosis" way, which provides another theoretical basis for the practical application of amino acid chelated iron.

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